TOX high mobility group box family member 3, also known as TOX3, is a human gene. The protein encoded by this gene is a member of a subfamily of transcription factors that also inc

Jan 15, 2026 · TOX3 (TOX High Mobility Group Box Family Member 3) is a Protein Coding gene. Diseases associated with TOX3 include Restless Legs Syndrome …

Our findings establish TOX3 as a driver for excessive gluconeogenesis through activating hepatic FoxO1 transcription. TOX3 could serve as a promising target for preventing and trea

Mar 18, 2026 · Here, we profile nearly 2,000 transcriptional regulators across multiple mouse organs and identify Tox3 as a key coactivator of Atoh1 in the cerebellum. Loss of Tox

Jan 11, 2013 · TOX3 is a member of the HMG-box protein family that regulates chromatin structure by bending and unwinding DNA. It is located on chromosome 16q12.1 and has been ass

Jan 4, 2025 · TOX3 gene variant could be associated with painful restless legs. TOX high mobility group box family member 3 (TOX3) is one such gene, in which SNPs have been found

Mar 1, 2024 · Furthermore, Tox3 knockout can both potently protect against as well as ameliorate hyperglycemia and gluconeogenesis in diabetic mice induced by high-fat diet. There

TOX3 plays a role in regulating calcium-dependent transcription and interacts with cAMP-response-element-binding protein (CREB) and CREB-binding protein (CBP). [7] It also increase

These results indicated that TOX3 is a prognostic indicator and promising immunomodulatory factor in lung adenocarcinoma. Future studies investigating …

In this study, we characterize the protein expression of TOX3 in breast tumors with respect to various clinical and pathological characteristics and explore the correlation between