https://pubmed.ncbi.nlm.nih.gov/8821061/
by G Bringmann · 1995 · Cited by 36 — TaClo exhibits highly selective in vitro inhibition of complex I of the mitochondrial respiratory chain, the required concentrations being
https://pubmed.ncbi.nlm.nih.gov/8821060/
by G Bringmann · 1995 · Cited by 64 — The TaClo concept: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), a new toxin for dopaminergic neurons. J Neural Transm Supp
https://www.sciencedirect.com/science/article/pii/S0304394019305403
by PC Keane · 2019 · Cited by 34 — TCE or TaClo exposure caused significant DA neuronal loss within the SNpc in both wild type and transgenic mice. Cell numbers were lower in A
https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/725426
by G Bringmann · 1996 · Cited by 28 — Furthermore, TaClo exhibits a strong inhibition of complex I of the mitochondrial respiratory chain. ... TaClo' even under mild quasi-phys
https://link.springer.com/chapter/10.1007/978-1-4615-1269-1_49
by SAS Yasin — TaClo (l-trichloromethyl-1,2, 3,4-tetrahydro-b-carboline), a highly chlorinated tetrahydro-ß-carboline is known to exert neurotoxic effects an the dopaminergic .
https://onlinelibrary.wiley.com/doi/10.1155/2019/1292891
Mar 7, 2019 — TaClo caused oxidative stress in the nigrostriatal system by increasing the production of reactive oxygen species and reducing the mitochondria membrane ...
https://europepmc.org/article/med/8821062
by WD Rausch · 1995 · Cited by 33 — 1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) is the first representative of a new class of highly halogenated heterocycles.
https://www.researchgate.net/figure/TaClo-reduces-cellular-ATP-levels-and-causes-phosphorylation-of-AMPK-a-150mM-TaClo_fig2_318571037
1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline, abbreviated as TaClo, is an endogenous neurotoxin capable of formation in the brain through the condensation ...
https://www.mdpi.org/ecsoc/ecsoc-4/c0001/c0001.htm
by G Bringmann — TaClo (4) was indeed found to penetrate the blood-brain barrier [5] and to develop toxic potencies against dopaminergic [6] and serotonergic [7] neurons.
https://www.andovercomputingopen.org/archive
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https://pubmed.ncbi.nlm.nih.gov/8821062/
by WD Rausch · 1995 · Cited by 33 — 1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) is the first representative of a new class of highly halogenated heterocycles.
https://exchemistry.com/chem-catalog/product-2076.html
Apr 29, 2024 — TaClo. CAS: 6649-90-7. TaClo is a dopaminergic and serotonergic neurotoxin. Catalog Number:EC-000.2076. Molecular Formula:C12H11Cl3N2. Molecular ...
https://pubmed.ncbi.nlm.nih.gov/10944002/
by G Bringmann · 2000 · Cited by 26 — Incubation experiments using the human serotonergic cell line JAR clearly revealed TaClo to significantly reduce serotonin (5-HT) uptake (
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4 letter words made by unscrambling letters TACLO · alco · alto · atoc · calo · clat · clot · coal · coat · cola · colt · loca · lota · octa · taco · talc ...
https://link.springer.com/article/10.1007/s12640-017-9782-1
by RK Sharma · 2017 · Cited by 16 — TaClo Depletes Cellular ATP Levels in Neuronal Cells. TaClo causes decrease in cellular ATP levels over time in both IMR-32 and SK-N-SH ...
https://pdfs.semanticscholar.org/01bb/b80f9e366fe6dff1bfffe842e58792121d7a.pdf
by Y Yang · 2019 · Cited by 8 — We hypothe- sized that TaClo causes PD symptoms by damaging the nigrostriatal system. Mitochondrial dysfunction, oxidative stress, and ...
https://www.researchgate.net/publication/288131767_Neurotoxic_effects_on_the_dopaminergic_system_induced_by_TaClo_1-trichloromethyl-1234-tetrahydro-b-carboline_a_potential_mammalian_alkaloid_In_vivo_and_in_vitro_studies
Aug 6, 2025 — Furthermore, TaClo exhibits a strong inhibition of complex I of the mitochondrial respiratory chain. Since tryptamine ('Ta') readily reacts with ...