https://social.technet.microsoft.com/Forums/office/en-US/09059b3a-5ab6-485a-ae1b-0de3b5de0c27/outlook-2010-default-calendar-item-notification-setting-not-saved
https://social.technet.microsoft.com/Forums/exchange/en-US/b1afc5a2-1d86-4c9b-8b3e-1c45afd7f030/time-service-issue-w32tm-resync-fails-with-access-is-denied-0x80070005
We have a Time Service issue on W2K8R2 DCs for a few days.