JWH 018 (Item No. 10900) is an analytical reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may ...
by F Zhou · 2025 · Cited by 2 — In the present study, we aimed to investigate the toxicity and underlying mechanisms of indole SCs JWH-018 and JWH-019 in mice (C57BL/6, male, 6
by F Zhou · Cited by 2 — Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro · Authors · Affiliations.
by O Malyshevskaya · 2017 · Cited by 51 — Natural cannabinoids and their synthetic substitutes are the most widely used recreational drugs. Numerous clinical cases describe acu
Dec 12, 2022 — This study provides an inventory of the synthetic cannabinoids detected in the EU from 2008 to 2022 and describes their structural evolution ...
JWH-018, arguably the most widely known synthetic cannabinoid, belongs to the group of aminoalkylindoles and is considered to be three times as potent as THC.
by JS Elmore · 2018 · Cited by 27 — Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Mal
JWH-018, also known as 1-pentyl-3-(1-naphthoyl)indole, is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both CB1 and ...
Aug 28, 2025 — Synthetic cannabinoids constitute the second largest and most diverse category of new psychoactive substances (NPS) available on the market ...
by KA Seely · 2012 · Cited by 79 — This study investigated the affinity and activity of a major metabolite, JWH-018-N-(5-hydroxypentyl) β-d-glucuronide (018-gluc), for CB1Rs.
JWH-018 is a synthetic cannabinoid agonist without the classical cannabinoid chemical structure. It was used in scientific research as a tool to study the ...
Background: JWH-018 was the first synthetic cannabinoid introduced as a legal high and the first of the new generation of novel psychoactive substances that ...
by SW Toennes · 2017 · Cited by 44 — Therefore, a pilot study was performed to assess adverse effects of JWH-018, which is one of the oldest and best known synthetic cannabinoi
Aug 6, 2025 — JWH-018 is a potent cannabinoid receptor agonist. Little is known about its pharmacology and toxicology in humans. This is the first research ...
by L Galindo · 2016 · Cited by 4 — JWH-018 was one of the first spice drugs. There is no scientific evidence of ... Its presence in the market seems decreasing. Disclosure of i